本成果研发了一种仿细胞外基质（ECM）成分的胶体、具有超快速成胶，湿面组织粘附强，生物相容性好，力学性能强的四大特点，能在30秒内快速止住60kg猪的左心室穿透伤高压大出血，具有重要的临床应用意义。

  In this study, we have designed a photo-reactive adhesive that mimicsthe extracellular matrix (ECM) composition. This biomacromolecule-basedmatrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV lightirradiation. These repairs can withstand up to 290 mmHg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60 to 160 mmHg). Most importantly, the hydrogel can stop high pressure bleeding from pig carotid arteries with 4~5 mm long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated andappears to offer significant clinical advantage as a traumatic wound sealant.

  欧阳宏伟，浙江大学求是特聘教授、爱丁堡大学荣誉教授，从事运动系统损伤修复与再生研究。先后入选国家杰出青年基金项目，爱思唯尔2015年-2018年中国高被引学者，国际骨科联合研究学会会士（ICORS Fellow）。现任浙大爱丁堡大学联合学院院长，浙大医学院副院长。
洪逸，浙江大学医学院副研究员，主要从事生物材料、快速生物3D光打印和组织工程相关领域的研究。中国组织工程学会青年会员，中国老年学和老年医学学会老年骨科分会创新转化学组委员会委员。主要研究成果发表在Nature Communications，Biomaterials，Applied Materials Today等杂志。